Publications

Research Articles

2014

Zhao B, Wu Z, Grillet N, Yan L, Xiong W, Harkins-Perry S, Müller U.

TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells.

Neuron. 2014 Dec 3;84(5):954-67. PubMed PDF

Highlighted in a Preview in the same issue by Liedtke W.

Xiong W, Wagner TF, Linxuan Y, Grillet N, Müller U.

Using injectoporation to deliver genes to mechanosensory hair cells.

Nat Protoc. 2014 Oct;9(10):2438-49. PubMed PDF

Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Müller U, Jones SM, Mustapha M.

Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.

Eur J Neurosci. 2014 Apr;39(8):1256-67. PubMed PDF

2012

Xiong W, Grillet N, Elledge HM, Wagner TF, Zhao B, Johnson KR, Kazmierczak P, Müller U.

TMHS is an integral component of the mechanotransduction machinery of cochlearhair cells.

Cell. 2012 Dec 7;151(6):1283-95. PubMed PDF

2011

Webb SW, Grillet N, Andrade LR, Xiong W, Swarthout L, Della Santina CC, Kachar B, Müller U.

Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain.

Development. 2011 Apr;138(8):1607-17. PubMed PDF

 

Borck G, Rehman AU, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, Nürnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, Nürnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, Müller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C.

Loss-of-Function Mutations of ILDR1 Cause Autosomal-Recessive Hearing Impairment DFNB42.

Am J Hum Genet. 2011 Jan 19. PubMed PDF

2009

Grillet N*, Schwander M*, Hildebrand MS, Sczaniecka A, Kolatkar A, Velasco J, Webster JA, Kahrizi K, Najmabadi H, Kimberling WJ, Stephan D, Bahlo M, Wiltshire T, Tarantino LM, Kuhn P, Smith RJ, Müller U.

Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.

Am J Hum Genet. PubMed PDF

Highlighted in the “Editor’s corner” of the same issue; * Shared first-authorship (Featured as Video Presentation in the American Museum of Natural History, New York, NY; The Frank H. McClung Museum, Knoxville, TN; Museum of Science and Industry, Chicago, IL; Great Lakes Science Center, Cleveland, OH; Estimated Audience: 6.650.000).

 

Grillet N*, Xiong W*, Reynolds A*, Kazmierczak P, Sato T, Lillo C, Dumont RA, Hintermann E, Sczaniecka A, Schwander M, Williams D, Kachar B, Gillespie PG, Müller U.

Harmonin mutations cause mechanotransduction defects in cochlear hair cells.
Neuron. 2009 May 14;62(3):375-87. PubMed PDF

Cover Article (see Gallery); highlighted in a Preview in the same issue by Heller et al.

Shared first-authorship

2008

Iankova I, Chavey C, Clapé C, Colomer C, Guérineau NC, Grillet N, Brunet JF, Annicotte JS, Fajas L.

Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.

Endocrinology. 2008 Nov;149(11):5706-12. PubMed PDF

2007

Schwander M, Sczaniecka A, Grillet N, Bailey JS, Avenarius M, Najmabadi H, Steffy BM, Federe GC, Lagler EA, Banan R, Hice R, Grabowski-Boase L, Keithley EM, Ryan AF, Housley GD, Wiltshire T, Smith RJ, Tarantino LM, Müller U.

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.

J Neurosci. 2007 Feb 28;27(9):2163-75. PubMed PDF

 

Herr DR, Grillet N, Schwander M, Rivera R, Müller U, Chun J.

Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2.

J Neurosci. 2007 Feb 7;27(6):1474-8. PubMed PDF

2001-2005

Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF.

Generation and characterization of Rgs4 mutant mice.

Mol Cell Biol. 2005 May;25(10):4221-8. PubMed PDF

 

Grillet N, Dubreuil V, Dufour HD, Brunet JF.

Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.

J Neurosci. 2003 Nov 19;23(33):10613-21. PubMed PDF

 

Garcès A, Livet J, Grillet N, Henderson CE, Delapeyrière O.

Responsiveness to neurturin of subpopulations of embryonic rat spinal motoneuron does not correlate with expression of GFR alpha 1 or GFR alpha 2.

Dev Dyn. 2001 Mar;220(3):189-97. PubMed PDF

Review Articles

The genetics of progressive hearing loss: a link between hearing impairment and dysfunction of mechanosensory hair cells.
Müller U, Grillet N*.
Future Neurol. 2010 Jan 1;5(1):9-12. PubMed PDF
*Corresponding author

 

[Harmonin is a component of the auditory mechanotransduction apparatus].
Grillet N.
Med Sci (Paris). 2009 Nov;25(11):903-6. doi: French. PubMed PDF

 

The mechanotransduction machinery of hair cells.
Grillet N, Kazmierczak P, Xiong W, Schwander M, Reynolds A, Sakaguchi H, Tokita J, Kachar B, Müller U.
Sci Signal. 2009 Aug 25;2(85):pt5. doi: 10.1126/scisignal.285pt5. PubMed PDF