14 Apr cover article published in J.Neuro !!!
Congratulation to the team, Alix, Katharine, Shefin, Noor, Pei and Tony!
About the paper:
“Hearing loss occurs frequently due to the dysfunction of the auditory sensory cells in the inner ear, which transform mechanical stimulations into electric signals. Trouillet et al. demonstrate that the molecule LOXHD1 is required for this mechanotransduction process, but surprisingly, only in mature auditory cells. When LOXHD1 is mutated, some of the known molecules required for mechanotransduction are still correctly positioned in the sensory cells, suggesting that the mechanotransduction machinery is still present, but not activatable. Their research identified a new step in the auditory cell development and a new mode of mechanotransduction regulation. It will be critical to further understand them as they are responsible for congenital and age-related forms of hearing loss in humans.”